An Anti- -Glucan Monoclonal Antibody Inhibits Growth and Capsule Formation of Cryptococcus neoformans In Vitro and Exerts Therapeutic, Anticryptococcal Activity In Vivo
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چکیده
Published Ahead of Print 2 July 2007. 2007, 75(11):5085. DOI: 10.1128/IAI.00278-07. Infect. Immun. Francesco Bistoni, Antonio Cassone and Anna Vecchiarelli Torosantucci, Paola Chiani, Carla Bromuro, Carla Proietti, Anna Rachini, Donatella Pietrella, Patrizia Lupo, Antonella Activity In Vivo Exerts Therapeutic, Anticryptococcal In Vitro and Cryptococcus neoformans Inhibits Growth and Capsule Formation of -Glucan Monoclonal Antibody β An Anti-
منابع مشابه
An anti-beta-glucan monoclonal antibody inhibits growth and capsule formation of Cryptococcus neoformans in vitro and exerts therapeutic, anticryptococcal activity in vivo.
In this study we tested the in vitro and in vivo anti-Cryptococcus neoformans activity of an antilaminarin (anti-beta-glucan) monoclonal antibody (MAb 2G8) (immunoglobulin G2b) which was previously shown to inhibit the growth of beta-glucan-exposing Candida albicans cells. Here we show that MAb 2G8 binds to the cell wall of C. neoformans and inhibits its growth to an extent comparable to that o...
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